Intrachromosomal recombination between direct repeats can occur either as gene conversion events, which maintain exactly the number of repeat units, or as deletions, which reduce the number of repeat units. Gene conversions are classical recombination events that utilize the standard chromosome recombination machinery. Spontaneous deletions between direct repeats are generally recA‐independent in E. coli and RAD52‐independent in S. cerevisiae. This independence from the major recombination genes does not mean that deletions form through a nonrecombinational process. Deletions have been suggested to (...) result from sister chromatid exchange at the replication fork in a recA‐independent process. The same type of exchange is proposed to be RAD52‐independent in Saccharomyces cerevisiae. RAD52‐dependent events encompass all events that involve the initial steps of a recombination reaction, which include strand invasion to form a heteroduplex intermediate. (shrink)

ABSTRACTRecognising identity and emotion conveyed by the face is important for successful social interactions and has thus been the focus of considerable research. Debate has surrounded the extent...

Volume 34, Issue 8, December 2020, Page 1621-1631.

_Highlights innovative partnership practices that help create educational opportunities for students in rural schools across the United States._ As editors Sara L. Hartman and Bob Klein acknowledge, rural places have long experienced systemic inequities that decrease rural students' access to education, yet many rural schools and communities have found creative means to make up for the dearth of outside resources. _The Middle of Somewhere_ brings to light a wide variety of partnerships that have been forged between K–12 schools, communities, (...) and postsecondary institutions to improve educational access. The book showcases collaborations that address three different areas of need: partnerships that prepare and support teacher candidates and educators who work in rural areas; partnerships that extend the work of rural education networks; and partnerships that promote equity, justice, and inclusion within rural populations. Using case studies of rural educational partnerships from communities across the United States, the book's contributors share their experiences of how strong partnerships have formed both organically and through thoughtful and intentional planning, and they recommend supportive strategies for their development and sustainment. The contributors also explore the many ways in which university–school–community partnerships incubate solutions to challenges common to rural education systems, such as access to STEM education and higher education. The programs featured here may serve as replicable models for practitioners, researchers, and policy makers who want to enrich the experiences of children in their schools and communities. (shrink)

We agree that external validity of social psychological experiments is a concern, we disagree these models are useless. Experiments, reconsidered from a situated cognition perspective and non-linearly combined with other methods allow grasping decision dynamics beyond bias outcomes. Dynamic insights regarding these processes are key to understand missing forces and bias in real-world social groups.

There is growing interest in nature-based interventions to improve human health and wellbeing. An important nascent area is exploring the potential of outdoor therapies to treat and prevent common mental health problems like depression. In this conceptual analysis on the nature–depression nexus, we distil some of the main issues for consideration when NBIs for depression are being developed. We argue that understanding the mechanisms, or ‘active ingredients’ in NBIs is crucial to understand what works and for whom. Successfully identifying modifiable (...) mediating intervention targets will pave the way for interventions with increased efficacy. We highlight a non-exhaustive list of five clinically relevant putative, candidate mechanisms which may underly the beneficial effects of NBIs on depression: stress, rumination, mindfulness, sleep and exercise. We also make the case that when developing NBIs it is important to not neglect young people, explore personalised approaches and focus on both treatment and prevention approaches. To achieve these aims methodologically rigorous programmes of clinical research are needed that include well-powered and controlled experimental designs including randomised controlled trials, qualitative research, longitudinal studies and large prospective cohorts. (shrink)

This text departs from a contradictory claim in deaf studies and sound studies: both disciplines describe a hierarchical regime of the sensible – visuocentrism and audiocentrism – which they try to counter with conceptualisations as “acoustemology” or “deaf gain.” However, as we argue, they both thereby erect what they claim to overcome: a sensual regime that privileges one sense over another and a restricted conception of subjectivity deriving from it. First, we draw a philosophical line in the critique of sensual (...) regimes. Then we propose a figure for the transcendence of the separation of the sensible: in re-reading of the myth of Odysseus and the sirens, we engage various examples from literature, art, and acoustics to describe sirens as a mythological and technical archetype of the transcendence of the sensual regime, as well as reified subjectivity. The question, then, is not how to escape the sirens, but how they can be approached. It is necessary, we argue, for sound studies to develop a critical self-consciousness of its own restricted concepts in order to move from sonic thinking towards a sirenic thinking. (shrink)

Analyzing the rate at which languages change can clarify whether similarities across languages are solely the result of cognitive biases or might be partially due to descent from a common ancestor. To demonstrate this approach, we use a simple model of language evolution to mathematically determine how long it should take for the distribution over languages to lose the influence of a common ancestor and converge to a form that is determined by constraints on language learning. We show that modeling (...) language learning as Bayesian inference ofnbinary parameters or the ordering ofnconstraints results in convergence in a number of generations that is on the order ofn log n. We relax some of the simplifying assumptions of this model to explore how different assumptions about language evolution affect predictions about the time to convergence; in general, convergence time increases as the model becomes more realistic. This allows us to characterize the assumptions about language learning (given the models that we consider) that are sufficient for convergence to have taken place on a timescale that is consistent with the origin of human languages. These results clearly identify the consequences of a set of simple models of language evolution and show how analysis of convergence rates provides a tool that can be used to explore questions about the relationship between accounts of language learning and the origins of similarities across languages. (shrink)

This paper presents the results of optical interferometry experiments in which the phase of photons in one arm of a Mach-Zehnder interferometer is modified by applying a transverse constriction. An equivalent quantum interferometry experiment using neutron de Broglie waves is discussed in which the observed phase shift is in the spirit of the force-free phase shift of the Aharonov-Bohm effects. In the optical experiments the experimental results are in excellent agreement with predictions.

These essays apply influential, pathbreaking psychological studies about women's lives to literature. In their analyses of fictional portraits, contributors both challenge and confirm psychological theories about female identity, about 'connection/separation' as developmental catalysts, and about the impact of gender on 'voice,' moral decision-making, and epistemology in relation to classical and contemporary literary texts, written by both women and men.

Darwinian Evolution and Classical Liberalism brings together a collection of new essays that examine the multifaceted ferment between Darwinian biology and classical liberalism.

Interest in the intersection between bilingualism and cognitive control and accessibility to neuroimaging methods have resulted in numerous studies with a variety of interpretations of the bilingual cognitive advantage. Neurocomputational Emergentism (or Neuroemergentism for short) is a new framework for understanding this relationship between bilingualism and cognitive control. This framework considers Emergence, in which two small elements are recombined in an interactive manner, yielding a non-linear effect. Added to this is the notion that Emergence can be captured in neural systems (...) using computationally inspired models. This review poses that bilingualism and cognitive control, as examined through the Neuroemergentist framework, are interwoven through development and involve the non-linear growth of cognitive processing encompassing brain areas that combine and recombine, in symbiotic and parasitic ways, in order to handle more complex types of processing. The models that have sought to explain the neural substrates of bilingual cognitive differences will be discussed with a reinterpretation of the entire bilingual cognitive advantage within a Neuroemergentist framework incorporating its neural bases. It will conclude by discussing how this new Neuroemergentist approach alters our view of the effects of language experience on cognitive control. Avenues to move beyond the simple notion of a bilingual advantage or lack thereof will be proposed. (shrink)

Ancient philosophy has from the outset inspired phenomenological philosophers in a special way. Phenomenological Interpretations of Ancient Philosophy offers fresh perspectives on the way ancient Greek thought has influenced phenomenology and traces the history of this reception. Unlike various related treatments, the present volume offers a broad account of this topic and includes chapters on Edmund Husserl, Martin Heidegger, Hans-Georg Gadamer, Jacob Klein, Hannah Arendt, Eugen Fink, Jan Patočka, Emmanuel Levinas, and Jacques Derrida.

In the context of climate change, the fallout from the COVID-19 pandemic, growing food insecurity, and rising inflation, the inequities in the dominant food system and subsequent vulnerabilities are being made ever more visible. Policies and programs that can support social and economic security while responding to intensifying environmental challenges are urgently needed. Basic income is receiving increasing attention as one such policy tool in jurisdictions around the world. However, its applications to food systems are underdeveloped. This discussion paper considers (...) basic income as a policy tool for supporting food systems sustainability in Canada drawing on our collaborative research as part of Coalition Canada’s Case for Basic Income Series. We suggest that a basic income may contribute to addressing precarity in livelihoods and food access while offering potential co-benefits for local food production and community well-being. We also underscore that basic income is not a panacea for all problems facing food systems and must be considered alongside other public supports and initiatives. We conclude by identifying areas for further research and policy investigation for food systems scholars and practitioners. (shrink)

Is 50 considered “old”? When do we stop being considered “young”? If individuals could choose to be any age, what would it be? In a sample of 502,548 internet respondents ranging in age from 10 to 89, we examined age differences in aging perceptions (e.g., how old do you feel?) and estimates of the timing of developmental transitions (e.g., when does someone become an older adult?). We found that older adults reported older perceptions of aging (e.g., choosing to be older, (...) feeling older, being perceived as older), but that these perceptions were increasingly younger than their current age. The age to which individuals hope to live dramatically increased after age 40. We also found that older adults placed the age at which developmental transitions occurred later in the life course. This latter effect was stronger for transitions involving middle-age and older adulthood compared to transitions involving young adulthood. The current study constitutes the largest study to date of age differences in age perceptions and developmental timing estimates and yielded novel insights into how the aging process may affect judgments about the self and others. (shrink)

Attention-Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, comorbidity and inhibitory control deficits have been proposed for both. Whilst such deficits have been studied widely within clinical populations, findings are mixed—partly due to comorbidity and/or medication effects—and studies have rarely distinguished between subtypes of the disorders. Studies in the general population are sparse. Using a continuity approach, the present study examined (i) the relationships between inattentive and hyperactive/impulsive aspects of ADHD and TS-like behaviors in (...) the general population, and (ii) their unique associations with automatic and executive inhibitory control, as well as (iii) yawning (a proposed behavioral model of TS). One hundred and thirty-eight participants completed self-report measures for ADHD and TS-like behaviors as well as yawning, and a conditioned inhibition task to assess automatic inhibition. A sub-sample of fifty-four participants completed three executive inhibition tasks. An exploratory factor analysis of the TS behavior checklist supported a distinction between phonic and motor like pure TS behaviors. Whilst hyperactive/impulsive aspects of ADHD were associated with increased pure and compulsive TS-like behaviors, inattention in isolation was related to reduced obsessive-compulsive TS-like behaviors. TS-like behaviors were associated with yawning during situations of inactivity, and specifically motor TS was related to yawning during stress. Phonic TS and inattention aspects of ADHD were associated with yawning during concentration/activity. Whilst executive interference control deficits were linked to hyperactive/impulsive ADHD-like behaviors, this was not the case for inattentive ADHD or TS-like behaviors, which instead related to increased performance on some measures. No associations were observed for automatic conditioned inhibition. (shrink)

Cet ouvrage est l'hommage qu'une des deux filles de Jean Klein (1912-1998), Nita, comédienne et artiste, a décidé de rendre à son père, un des plus célèbres maîtres spirituels du XXe siècle, pour le centième anniversaire de sa naissance. Nita Klein a rassemblé ici de nombreux souvenirs de conversations avec Jean Klein, des inédits, des photographies autour de la question de l'art et de la spiritualité. Jean Klein a été philosophe et un maître spirituel remarquable auteur (...) d'une oeuvre essentielle qui a infuencé de nombreux enseignants contemporains comme Eric Baret, Jean-Bouchart D'Orval, Francis Lucille, Jean-Marc Mantel etc. Même si Jean Klein n'appartenait à aucune école, sa quête de la vérité a rencontré l'Advaïta Vedânta (Non-Dualité) dont il a dit lui-même que " ce n'est pas un système, une religion, une technique. Ce n'est même pas une philosophie, c'est simplement la vérité. " Mais Jean Klein était aussi violoniste (il pratiqua toute sa vie le violon) et s'intéressait à toutes les formes d'art : au théâtre, à la peinture (il était ami de Hans Hartung), à la danse (son autre fille, Malavika, est professeur de danse indienne). Il s'agit donc dans ce livre d'une rencontre entre l'intuition d'un artiste et la recherche indienne de la vérité, recherche plus orientée vers la perception globale de la Réalité que vers les certitudes offertes par le savoir. Nita Klein nous invite à découvrir comment la spiritualité authentique conduit à la création artistique ; comment, dans l'art du théâtre, l'interprétation d'un personnage, peut atteindre à la vérité, quand la personnalité du comédien consent à s'effacer. " En l'absence du "Moi", il y a seulement la vie. ", dit Jean Klein. Et pas seulement dans le théâtre, mais dans la peinture, le dessin, la danse. La Non-Dualité, avec Jean Klein, est une ouverture à la Beauté. (shrink)

Scholarship on the Republic has tended to stress the centrality of the tripartite soul to the Republic’s conception of justice. Yet since Socrates’s task in the dialogue is to show the desirability of justice in the ordinary Athenian sense, any emphasis on idiosyncratic psychology would render his account of justice fundamentally beside the point. This paper suggests a way out of this dilemma. It argues that Platonic justice in the Republic represents a shrewd twist on the entirely conventional, distributive Athenian (...) notion of justice as refraining from seizing for oneself what belongs to another. Plato’s twist is to substitute the performance of one’s own activity (πρᾶξις τα ἑαυτοῦ) for the possession of one’s household goods (ἕξις τα ἑαυτοῦ) as the proper object of justice. The paper then shows how this account of Platonic justice makes sense both textually and contextually, before concluding. (shrink)

This book examines influential conceptions of sport and then analyses the interplay of challenging borderline cases with the standard definitions of sport. It is meant to inspire more thought and debate on just what sport is, how it relates to other activities and human endeavors, and what we can learn about ourselves by studying sport.

The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome can be worse for females. Females mount higher innate and adaptive immune responses than males, which can result in faster clearance of viruses, but also contributes to increased development of immunopathology. In response to viral vaccines, females mount higher antibody responses and experience more adverse reactions than males. The efficacy of antiviral drugs at reducing viral load differs between the sexes, and the adverse reactions to (...) antiviral drugs are typically greater in females than males. Several variables should be considered when evaluating male/female differences in responses to viral infection and treatment: these include hormones, genes, and gender‐specific factors related to access to, and compliance with, treatment. Knowledge that the sexes differ in their responses to viruses and to treatments for viral diseases should influence the recommended course of action differently for males and females.Editor's suggested further reading in BioEssays X‐chromosome‐located microRNAs in immunity: Might they explain male/female differences Abstract. (shrink)

Misophonia has been characterized as intense negative reactions to specific trigger sounds. However, recent research suggests high-level, contextual, and multisensory factors are also involved. We recently demonstrated that neurotypicals’ negative reactions to aversive sounds are attenuated when the sounds are synced with positive attributable video sources. To assess whether this effect generalizes to misophonic triggers, we developed a Sound-Swapped Video database for use in misophonia research. In Study 1, we created a set of 39 video clips depicting common trigger sounds (...) and a corresponding set of 39 PAVS temporally synchronized with the OVS videos. In Study 2, participants rated the 39 PAVS videos for their audiovisual match and pleasantness. We selected the 20 PAVS videos with best match scores for use in Study 3. In Study 3, a new group of participants observed the 20 selected PAVS and 20 corresponding OVS and judged the pleasantness or unpleasantness of each sound in the two contexts accompanying each video. Afterward, participants completed the Misophonia Questionnaire. The results of Study 3 show a robust attenuating effect of PAVS videos on the reported unpleasantness of trigger sounds: trigger sounds were rated as significantly less unpleasant when paired with PAVS with than OVS. Moreover, this attenuating effect was present in nearly every participant regardless of their score on the MQ. In fact, we found a moderate positive correlation between the PAVS-OVS difference and misophonia severity scores. Overall our results provide validation that the SSV database is a useful stimulus database to study how misophonic responses can be modulated by visual contexts. Here, we release the SSV database with the best 18 PAVS and 18 OVS videos used in Study 3 along with aggregate ratings of audio-video match and pleasantness. We also provide detailed instructions on how to produce these videos, with the hope that this database grows and improves through collaborations with the community of misophonia researchers. (shrink)

Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examined instead, due to their accessibility. As such, the reliability of using the peripheral epigenome as a proxy for that of the brain is imperative. Previously, our lab has found aberrant methylation at the Brain-derived neurotrophic factor gene (...) in the prefrontal cortex of rats following aversive caregiving. The current study examined whether aversive caregiving alters Bdnf DNA methylation in the blood compared to the prefrontal cortex. It was revealed that DNA methylation associated with adversity increased in both tissues, but this methylation was not correlated between tissues. These findings indicate that group trends in Bdnf methylation between blood and the brain are comparable, but variation exists among individual subjects. (shrink)

I. Les facultés qui se rapportent à l'image des objets en nous, — l'imagination au sens large, — constituent, selon une tradition qui vient d'Aristote, l'intermédiaire entre la sensibilité et l'intellect. Le moyen âge les désigna par le nom de sens intérieurs ; leur liste fut reprise et modifiée par Ficin (dont la source directe n'est pas Avicenne, mais Albert le Grand) et par Bruno. Dans l'interprétation des néoplatoniciens, la série des facultés connaissantes représente le chemin de l'âme dans la (...) conversion ; la phantasia y joue un rôle eminent (Plotin, Hugues de Saint-Victor, Ficin, Bruno) ; d'autre part, on fait correspondre à la faculté intermédiaire une âme intermédiaire qui lui sert de substrat (Lulle), et un « premier corps » ou « véhicule » de l'âme (le spiritus phantasticus ou őχημα-πνεῦμα de Synesius). L'idée reparaît, modifiée, chez Hugues de Saint-Victor, Ficin, Bruno. Ce dernier met le spiritus phantasticus en relation avec l'âme du monde, qui lui est consubstantielle, la « lumière précédant toute Création » qui nous fait voir les images de nos rêves. Sources : Porphyre, Cusanus repris par Ficin, le panthéisme médiéval. Le lien entre le spiritus phantasticus et le destin de l'âme, esquissé chez Plotin, Porphyre, le Pseudo-Jamblique, Synesius, est affirmé sous différentes formes par Hugues, Ficin et Bruno : le sujet des peines infernales, qui sont d'ailleurs chez Ficin et Bruno de nature imaginaire, est un corps subtil. Ces peines correspondent exactement à ce que nos appétits et notre imagination ont fait de la substance de notre âme. Le spiritus phantasticus se rapproche, notamment chez Ficin, d'une sorte de karma. II. Dans la branche descendante de la connaissance, l'application de l'universel au particulier est forcément liée au sens intérieur et on l'attribue à une faculté spéciale, la Urteilskraft au sens kantien. Bruno en fait une fonction de l'imagination. D'autre part, les arts universels ou lulliens ont pris de plus en plus, durant la Renaissance, l'aspect de topiques généralisées ; le nerf de la méthode y était donc toujours cette Urteilskraft. Il s'en suit, chez Bruno, que le sujet de l'art universel est l'imagination, qui devient ainsi la source première de tout acte de l'intellect, principe de la fécondité infinie de la pensée. (Pratiquement, d'ailleurs, les artes de Bruno sont des ensembles d'images). III. Aux théories de l'imagination répondent les théories de l'image, « vêtement » et « premier corps » de la pensée. On vérifie cette correspondance, d'une part, dans la théorie du symbole, — avec ses variantes métaphysiques, pansymbolisme, magie, — et, d'autre part, dans celle du concetto (rapport entre la pensée et l'expression), où l'on va jusqu'à l'idée d'un universel de l'imagination, et du dessin comme concept. — Une importante différence entre la nature du symbolisme selon Pic et l'idée que s'en fait Bruno s'explique par leurs conceptions différentes de l'imagination. La théorie de l'art et l'évolution du goût artistique sont, dans leurs grandes lignes, en concordance avec ce qu'impliquent ou suggèrent à ce sujet les théories de l'imagination et de l'image. (shrink)

Perceived behavioral integrity involves the employee’s perception of the alignment of the manager’s words and deeds. This meta-analysis examined the relationship between perceived behavioral integrity of managers and the employee attitudes of job satisfaction, organizational commitment, satisfaction with the leader and affect toward the organization. Results indicate a strong positive relationship overall (average r = 0.48, p<0.01). With only 12 studies included, exploration of moderators was limited, but preliminary analysis suggested that the gender of the employees and the number of (...) levels between the employee and the manager are potential moderators of the relationship. In the current sample of studies, country where the research was conducted did not seem to have any moderating effects. In addition to suggesting further investigation of potential moderators, we call for research that examines the relationship between behavioral integrity and outcomes that include individual behavior and organizational performance. (shrink)

BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

L'incommensurable fait apparaître qu'il est des fêlures irréductibles dans notre expérience révélant de l'infini du sein même de cette expérience: entre le plaisir et la jouissance ou bien le rapport social et l'intime. L'inouï dit, non pas l'extraordinaire ou l'insolite, mais ce qui peut être au contraire le plus commun de notre expérience--mais que nous n'entendons pas parce que nous ne savons pas déborder les cadres figés de cette expérience. La vraie vie fait signe vers ce que, tout en étant (...) en vie, nous risquons de n'être toujours que dans une apparence de vie, ou pseudo-vie, sans accéder à vraiment vivre. Trois concepts proposés par François Jullien pour ne pas laisser rabattre notre vie, mais la porter à son déploiement. Contre les facilités du prêche et du marché du Bonheur, il faut penser ces concepts comme outils pour 'changer la vie.'"--Page 4 of cover. (shrink)